| 标题： | 创伤/失血性休克后期肺损伤的性别差异 |
| 摘要： |
背景与目的：我们以前的研究发现：创伤/失血性休克(T/HS) 复苏后早期（3小时）肺损伤明显，雌性动物较雄性动物耐受性强。但是，T/HS后期肺损伤是否依然存在，是否具有性别差异目前仍然未知，本研究观察雌、雄动物T/HS 后期肺损伤的差异。 方法：雌、雄性SD大鼠剖腹（创伤）后经颈动脉放血致T/HS或假休克(T/SS)，90分钟后休克大鼠用乳酸林格氏液(RL)复苏；复苏后5天评估肺损伤的情况。 结果：T/HS后大鼠的肺通透性、肺髓过氧化物酶（MPO）水平以及支气管肺泡灌注液（BALF）蛋白浓度与血浆蛋白浓度的比值增加，雌性大鼠的上述变化与雄性大鼠相比更加显著。 结论：创伤/失血性休克5天后仍然存在肺损伤，而且有显著的性别差异，雌雄大鼠肺损伤较雄性大鼠更重。 |
| 英文摘要： | Background and aims ：Previously We have documented that lung injury after trauma-hemorrhagic shock (T/HS) is significant 3 hours after resuscitation and that females are more resistant to T/HS-induced lung injury than males. However, it is not known if the lung injury and its gender dimorphrism still exsit 5 days after resuscitation. Therefore, We aim to determine the lung injury after T/HS and to compare its gender difference 5 days after resuscitation. Methods：Male and female Sprague-Dawley rats were subjected to a midline laparotomy (trauma) and either hemorrhagic shock or sham shock. At the end of the shock period, the animals were resuscitated with Ringer lactate 3 times of their shed blood. Five days postresuscitation, the animals were sacrificed and lung permeability was measured . Results：Lung permeability and pulmonary leukosequestration in T/HS animals were increased significantly 5 days In contrast to what seen 3 hours post-resuscitation, lung injury of female animals were more severe than male. That is, Females subjected to T/HS had increased pulmonary permeability, increased BALF protein/plasma protein ratio and increased pulmonary myeloperoxidase levels than males. Males gained while females lost body weight during study period. Conclusion：Lung injury still can be seen 5 days aftar resuscitation. The injury is more severe in female than in male. |
| 作者： |
石汉平；何裕隆；王深明；韩方海；张常华；马晋平；詹文华 |
| 作者单位： | |
| 期刊： | 中华普通外科学文献(电子版) |
| 年.卷(期):页码 | 2007 .1（4）：212-214 |
| 中图分类号： | |
| 文章编号： | |
| 引用格式： | [1]石汉平；何裕隆；王深明；韩方海；张常华；马晋平；詹文华.创伤/失血性休克后期肺损伤的性别差异[J/CD].中华普通外科学文献（电子版）,2007,1(4):212-214. |
| 关键词： | 创伤/失血性休克；性别；大鼠；肺损伤 |
| 英文关键词： | Trauma/hemorrhagic shock；Rat；Gender；Lung injury |
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