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中华普通外科学文献简介:中华普通外科学文献简介,中华普通外科学文献简介[详细]

期刊信息

主管:
中华人民共和国国家卫生健康委员会
主办:
中华医学会
承办:
中山大学附属第一医院
中山大学附属中山医院
出版:
中华医学电子音像出版社有限责任公司
总编辑: 王深明
编辑部主任: 汪谦
刊 期: 双月刊
创刊时间: 2007年2月
国内刊号: 11-9148/R
国际刊号: 1674-0793
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首页 > 期刊列表 > 创伤/失血性休克后期肺损伤的性别差异
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标题: 创伤/失血性休克后期肺损伤的性别差异
摘要:

背景与目的:我们以前的研究发现:创伤/失血性休克(T/HS) 复苏后早期(3小时)肺损伤明显,雌性动物较雄性动物耐受性强。但是,T/HS后期肺损伤是否依然存在,是否具有性别差异目前仍然未知,本研究观察雌、雄动物T/HS 后期肺损伤的差异。 方法:雌、雄性SD大鼠剖腹(创伤)后经颈动脉放血致T/HS或假休克(T/SS),90分钟后休克大鼠用乳酸林格氏液(RL)复苏;复苏后5天评估肺损伤的情况。 结果:T/HS后大鼠的肺通透性、肺髓过氧化物酶(MPO)水平以及支气管肺泡灌注液(BALF)蛋白浓度与血浆蛋白浓度的比值增加,雌性大鼠的上述变化与雄性大鼠相比更加显著。 结论:创伤/失血性休克5天后仍然存在肺损伤,而且有显著的性别差异,雌雄大鼠肺损伤较雄性大鼠更重。

英文摘要: Background and aims :Previously We have documented that lung injury after trauma-hemorrhagic shock (T/HS) is significant 3 hours after resuscitation and that females are more resistant to T/HS-induced lung injury than males. However, it is not known if the lung injury and its gender dimorphrism still exsit 5 days after resuscitation. Therefore, We aim to determine the lung injury after T/HS and to compare its gender difference 5 days after resuscitation. Methods:Male and female Sprague-Dawley rats were subjected to a midline laparotomy (trauma) and either hemorrhagic shock or sham shock. At the end of the shock period, the animals were resuscitated with Ringer lactate 3 times of their shed blood. Five days postresuscitation, the animals were sacrificed and lung permeability was measured . Results:Lung permeability and pulmonary leukosequestration in T/HS animals were increased significantly 5 days In contrast to what seen 3 hours post-resuscitation, lung injury of female animals were more severe than male. That is, Females subjected to T/HS had increased pulmonary permeability, increased BALF protein/plasma protein ratio and increased pulmonary myeloperoxidase levels than males. Males gained while females lost body weight during study period. Conclusion:Lung injury still can be seen 5 days aftar resuscitation. The injury is more severe in female than in male.
作者:

石汉平;何裕隆;王深明;韩方海;张常华;马晋平;詹文华

作者单位:
期刊: 中华普通外科学文献(电子版)
年.卷(期):页码 2007 .1(4):212-214
中图分类号:
文章编号:
引用格式: [1]石汉平;何裕隆;王深明;韩方海;张常华;马晋平;詹文华.创伤/失血性休克后期肺损伤的性别差异[J/CD].中华普通外科学文献(电子版),2007,1(4):212-214.
关键词: 创伤/失血性休克;性别;大鼠;肺损伤
英文关键词: Trauma/hemorrhagic shock;Rat;Gender;Lung injury

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