


标题: | 胃癌组织中p-mTOR表达与患者预后的关系 |
摘要: |
目的:探讨中国人胃癌组织中哺乳动物雷帕霉素靶蛋白(mTOR)的活化形式p-mTOR蛋白的表达与胃癌预后的关系。 方法:采用免疫组化方法检测181例胃癌组织中p-mTOR蛋白的表达情况,分析其与胃癌预后的关系。单因素分析采用 Kaplan-Meier法计算患者存活率并比较平均生存时间,多因素分析用 COX 回归模型。 结果:181例胃癌标本中p-mTOR蛋白表达阳性93例,阳性表达率为51.4%。与p-mTOR表达阴性患者比较,其阳性患者的患者总存活率与无病存活率明显缩短(组间比较DFS, P |
英文摘要: | Objective:To investigate the prognostic significance of activated mTOR (p-mTOR) expression in gastric cancer patients undergoing curative surgery. Methods:The expression of p-mTOR was detected in specimens of 181 gastric cancers who underwent radical resection (R0) by immunohistochemistry. The influence of each variable on survival was analyzed by the multivariate analysis of Cox proportional hazard model. Results:The positive rate of p-mTOR in gastric cancer was 51.4%. Patients with p-mTOR positive showed significantly shorter disease-free survival (DFS) and overall survival (OS) rates than those with p-mTOR-negative tumors in univariate analyses (DFS, P |
作者: |
徐大志;侯景辉;詹友庆;周志伟;李威;陈映波;孙晓卫;关远祥;李元方;林桐榆 |
作者单位: | |
期刊: | 中华普通外科学文献(电子版) |
年.卷(期):页码 | 2009 .3(6):495-498 |
中图分类号: | |
文章编号: | |
引用格式: | [1]徐大志;侯景辉;詹友庆;周志伟;李威;陈映波;孙晓卫;关远祥;李元方;林桐榆.胃癌组织中p-mTOR表达与患者预后的关系[J/CD].中华普通外科学文献(电子版),2009,3(6):495-498. |
关键词: | 胃癌;p-mTOR;免疫组化 |
英文关键词: | Gastric cancer;p-mTOR;Immunohistochemistry |
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