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中华普通外科学文献简介:中华普通外科学文献简介,中华普通外科学文献简介[详细]

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中华人民共和国国家卫生健康委员会
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中华医学会
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首页 > 期刊列表 > 入肝门静脉动脉化加门腔分流术对肝硬化大鼠血流动力学的影响
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标题: 入肝门静脉动脉化加门腔分流术对肝硬化大鼠血流动力学的影响
摘要:

目的:对肝硬化大鼠利用右肾动脉行入肝门静脉动脉化+门腔分流术,研究该术式对肝硬化大鼠门静脉血流动力学的影响。 方法:四氯化碳(CCl4)诱导肝硬化大鼠成模后,分为A组(动脉化组)15只,利用右肾动脉行门静脉动脉化+门腔分流术,B组(对照组)10只,单纯行右肾切除及门静脉阻断10 min后关腹。术后即刻、术后1月和术后3月分别检测门静脉压力、内径和血流量。 结果:术后即刻、术后1月和术后3月A组大鼠与B组相比,入肝门静脉压力和入肝血流量明显升高,随时间推移入肝门静脉压力有下降趋势,但仍高于对照组(P

英文摘要: Objective:To investigate the effect of portal vein arterialization(PVA) associated with portacaval shunt on hepatic hemodynamics. Methods:Twenty-five Sprague-Dawley rats with liver cirrhosis were divided into two groups randomly. Group A( PVA group) : to establish the PVA model by the right renal artery after portacaval shunt. Group B(control group): right nephrectomy and temporary occlusion of portal vein for 10 minutes. The pressure, diameter and blood inflow of portal vein were investigated at the end of operation, 1 month and 3 month after operation, respectively. Results:In group A, the pressure, diameter and blood inflow of portal vein increased significantly after surgery. The portal vein pressure fell slowly with the passage of time, but were still significantly higher than group B within 3 postoperative months. The diameter and hepatic blood inflow was risen significantly after surgery, and continued within 3 months. However, there was no significantly difference between the postoperative 1 month and 3 month of the diameter. At 3 postoperative month, the hepatic blood inflow was markedly higher than 1 postoperative month. The pressure of the caval inflow portal stem decreased obviously after surgery. Conclusions:PVA associated with portocaval Shunt reduce the pressure of portal system collateral circulation effectively, minimize the risk of hemorrhage, furthermore the hepatic blood inflow was increased significantly, hence improve the blood and oxygen supply. The pressure and diameter of the portal vein achieve a new balance at a high level and become stable within 3 months after surgery.
作者:

刘琦;李坚;关晓东;郭辉;蔡潮农;张百萌

作者单位: 珠海,中山大学附属第五医院普外3科(刘琦、李坚、关晓东、蔡潮农、张百萌),超声科(郭辉)
期刊: 中华普通外科学文献(电子版)
年.卷(期):页码 2010 .4(2):109-113
中图分类号:
文章编号:
引用格式: [1]刘琦;李坚;关晓东;郭辉;蔡潮农;张百萌.入肝门静脉动脉化加门腔分流术对肝硬化大鼠血流动力学的影响[J/CD].中华普通外科学文献(电子版),2010,4(2):109-113.
关键词: 门静脉动脉化 肝硬化 门腔分流 血流动力学
英文关键词: Portal Vein Arterialization;Liver cirrhosis;Portacaval shunt;Hemodynamics

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