


标题: | 谷氨酰胺对胃癌术后化疗患者肠屏障功能的影响 |
摘要: |
目的:观察谷氨酰胺对胃癌术后化疗患者肠屏障功能的影响。 方法:40例胃癌术后第4次化疗患者随机分为对照组和试验组,化疗方案为氟尿嘧啶(5-FU)、四氢叶酸(CF)加奥沙利铂(FOLFOX方案)。试验组化疗同时口服谷氨酰胺(30 g/d),对照组化疗时未口服谷氨酰胺,检测两组患者化疗前后血浆谷氨酰胺浓度、二胺氧化酶(DAO)、D-乳酸水平及粪便中肠道菌群情况。 结果:化疗后对照组血浆谷氨酰胺浓度较化疗前明显降低(P<0.05),试验组增加并明显高于对照组(P<0.01);化疗后两组血浆DAO水平较化疗前均明显升高(P<0.01),对照组较试验组升高更为明显(P<0.05);对照组D-乳酸水平化疗后升高(P<0.05),与试验组比较差异有统计学意义;试验组患者各肠道菌群总数化疗前后无明显变化,肠道菌群接近正常比例;对照组双歧杆菌、乳杆菌较化疗前明显下降(P<0.01),大肠埃希菌、肠球菌明显升高(P<0.01)。 结论:口服谷氨酰胺可提高胃癌术后化疗患者血浆谷氨酰胺浓度,有减轻损伤、调节肠道菌群微生态平衡、保护肠屏障功能的作用。 |
英文摘要: | Objective:To study the effects of glutamine on intestinal barrier function in patients undergoing postoperative chemotherapy for gastric cancer. Methods:Forty patients with gastric cancer after operation who accepted the fourth chemotherapy were randomly divided into Gln group and control group. The former received oral administration of glutamine (30 g/d) for 7 days. All patients received CF+5-FU+Oxalipatin chemotherapy, namely FOLFOX formula, for 5 days. Serum concentration of glutamine, DAO and D-lactate were measured before and l day after chemotherapy. Changes of microflora in stool were also studied by bacterial culture. Results:After chemotherapy, the serum concentration of glutamine was significantly decreased in the control group(P<0.05)and increased in the Gln group(P<0.01), and there was significant difference between the two groups(P |
作者: |
赵晓雷;何效东;崔泉;邓志云;杨毅 |
作者单位: | 深圳,武警广东边防总队医院外一科 |
期刊: | 中华普通外科学文献(电子版) |
年.卷(期):页码 | 2010 .4(2):132-134 |
中图分类号: | |
文章编号: | |
引用格式: | [1]赵晓雷;何效东;崔泉;邓志云;杨毅.谷氨酰胺对胃癌术后化疗患者肠屏障功能的影响[J/CD].中华普通外科学文献(电子版),2010,4(2):132-134. |
关键词: | 谷氨酰胺 胃癌 化疗 肠屏障功能 |
英文关键词: | Glutamine;Gastric cancer;Chemotherapy;Intestinal barrier function |
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