


标题: | 干细胞标记物Lgr5在胃癌组织中的表达及临床意义 |
摘要: |
目的:分析干细胞标记物Lgr5(富含亮氨酸重复单位的G蛋白偶联受体5)蛋白在人胃癌组织中的异常表达,并探讨在胃癌肿瘤的发生发展等过程中发挥的作用。方法:选取2012年1月至2015年6月接受胃癌手术治疗的70例患者,采用免疫组化法分别检测70例胃正常组织、癌旁组织、胃腺癌标本中Lgr5的蛋白表达,并统计学分析其与临床病理指标、患者生存预后的关系。结果:70例胃癌组织中的Lgr5蛋白阳性表达率(50/70,71.4%)明显高于癌旁组织(35/70,50.0%)、正常组织(21/70,30.0%),差异有统计学意义(c2=6.738、24.034,P=0.009、0.000);Lgr5蛋白的表达与胃癌患者的性别、年龄及分化程度无明显相关性,与淋巴结节转移、TNM分期密切相关(均P<0.05)。随访胃癌患者66例,其中Lgr5阳性组47例,Lgr5阴性组19例,生存分析两组术后3年生存率差异有统计学意义(c2=3.929,P=0.047)。结论:Lgr5蛋白在胃癌发生过程中可能发挥一定作用,它与胃癌的侵袭、转移和预后明显相关,Lgr5的表达检测可作为判断胃癌患者预后的一种手段。 |
英文摘要: | Objective:To investigate the expression and its significance of Lgr5 protein in gastric cancer. Methods:Lgr5 expression was detected by immunohistochemistry in normal tissues, paracancerous tissues and gastric cancer tissues of 70 patients with gastric cancer treated from January 2012 to June 2015. Clinicopathological information and prognosis data of these 70 patients were analyzed to figure out the role of Lgr5 in gastric cancer. Results:The expression rate of Lgr5 in tumor tissues (50/70, 71.4%) was significant higher than that in both normal tissues (21/70, 30.0%, c2=24.034, P=0.000) and paracancerous tissues (35/70, 50.0%, c2=6.738, P=0.009). Lgr5 expression was significantly correlated with TNM stage and lymph node metastasis. There was no correlation between expression of Lgr5 with age, differentiation, and clinical characteristics in gastric cancer. Kaplan-Meier analysis showed significant difference in 3-year survival rates between groups with and without Lgr5 expression (c2=3.929, P=0.047). Conclusions:Expression of Lgr5 in gastric cancer indicates that stem cells may be involved in the pathogenesis of gastric cancer and Lgr5 may play an important role in the development and progression of gastric cancer. Lgr5 expression might be a useful marker of poor prognosis in gastric cancer. |
作者: |
黄江龙;魏波;郑宗珩;刘健培;陈图锋;黄勇;方佳峰 |
作者单位: | 510630 广州,中山大学附属第三医院胃肠外科 |
期刊: | 中华普通外科学文献(电子版) |
年.卷(期):页码 | 2016 .10(6):406-409 |
中图分类号: | |
文章编号: | |
引用格式: | [1]黄江龙;魏波;郑宗珩;刘健培;陈图锋;黄勇;方佳峰.干细胞标记物Lgr5在胃癌组织中的表达及临床意义[J/CD].中华普通外科学文献(电子版),2016,10(6):406-409. |
关键词: | 胃肿瘤 干细胞 亮氨酸 G蛋白偶联受体激酶5 |
英文关键词: | Stomach neoplasms;Stem cell;Leucine;G-protein-coupled receptor kinase 5 |
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