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中华普通外科学文献简介:中华普通外科学文献简介,中华普通外科学文献简介[详细]

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首页 > 期刊列表 > 术前短程辅助化疗对结直肠癌患者抑癌基因CDX2和生长抑制因子4表达的影响
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标题: 术前短程辅助化疗对结直肠癌患者抑癌基因CDX2和生长抑制因子4表达的影响
摘要:

目的:探讨术前短程辅助化疗联合根治性手术治疗结直肠癌的临床疗效,评估术前短程化疗对结直肠癌患者组织CDX2和生长抑制因子4(ING4)表达的影响。方法:回顾性分析2013年1月至2016年12月如皋博爱医院收治的112例结直肠癌患者资料,其中32例患者直接接受根治性手术切除病灶(对照组),80例在根治性手术前接受短程辅助化疗(研究组),采用免疫组织化学方法对两组活检组织中的CDX2和ING4表达进行定量分析,评估围手术期患者患者恢复情况,术后患者肛门排气时间、下床活动时间、住院时间、并发症发生情况,随访并应用Kaplan-Meier生存曲线进行单因素生存分析。结果:(1) 对照组和研究组患者的基本病理资料差异无统计学意义,具有可比性。(2) 2组治疗前CDX2和ING4的评分和阳性率均差异无统计学意义。化疗后研究组病灶样本中CDX2和ING4的免疫组化评分分别为8.33±1.86和8.86±2.31,阳性率分别为83.75%和72.50%,均显著高于对照组的5.86±2.41、6.83±1.57、59.38%、53.13%和化疗前水平的6.55±2.09、6.95±2.13、59.38%、57.50%。(3)与对照组相比,研究组患者的下床活动时间更早(P=0.033),但肛门排气时间和住院时长差异无统计学意义(P=0.235、0.332)。(4) 随访39个月时,研究组死亡率显著低于对照组(6.25% vs 15.63%,P<0.05)。结论:术前短程辅助化疗能显著提高结直肠癌患者肿瘤CDX2和ING4蛋白表达,对局部病灶有一定抑制作用,改善患者预后。

英文摘要: Objective:To evaluate the clinical efficacy of preoperative short-term adjuvant chemotherapy combined with radical surgery for colorectal cancer (CRC) patients, and the effect on the expression of tissue CDX2 and growth inhibitory factor 4 (ING4). Methods:From January 2013 to December 2016, the data of one hundred and twelve patients with CRC in Rugao Boai Hospital were analyzed retrospectively. Thirty-two patients underwent radical resection (control group), 80 patients received short range adjuvant chemotherapy before radical surgery (test group). The biopsies expressions of CDX2 and ING4 in two groups were analyzed by immunohistochemistry. The recovery during perioperative period, anal exhaust time, ambulation time, hospitalization time and complications of the patients were analyzed. The follow-up data were collected for univariate survival analysis by Kaplan-Meier survival curves. Results:(1) The basic pathological data of the patients between the two groups were not statistically significant. (2) The scoring and positive rates of CDX2 and ING4 were comparable between the two groups without significant difference. The post-operative histochemical scoring of CDX2 and ING4 of the test group were 8.33±1.86 and 8.86±2.31 (positive rate: 83.75% and 72.50%, respectively), significantly higher than the control group (5.86±2.41 and 6.83±1.57, positive rate: 59.38% and 53.13%) and pre-operative level (6.55±2.09 and 6.95±2.13, positive rate: 59.38% and 57.50%). (3) Compared with the control group, the ambulation time of the test group was earlier (P=0.033), while no statistically significant difference was detected for anal exhaust time (P=0.235) and hospitalization time (P=0.332). (4) The mortality rate of the test group during the 39-month follow-up was significantly lower than the control group (6.25% vs 15.63%, P<0.05). Conclusion:Preoperative short-term adjuvant chemotherapy can significantly improve the expression of CDX2 and ING4 protein in colorectal cancer patients, and improve the prognosis by providing certain inhibitory effect on the lesion.
作者:

孙健1;顾晓华1;侯卓2;周晓俊3

作者单位: 南通,江苏省如皋博爱医院普外科1,放射介入科2;苏州大学附属第一医院胃肠外科3
期刊: 中华普通外科学文献(电子版)
年.卷(期):页码 2017 .11(6):394-398
中图分类号:
文章编号:
引用格式: [1]孙健1;顾晓华1;侯卓2;周晓俊3.术前短程辅助化疗对结直肠癌患者抑癌基因CDX2和生长抑制因子4表达的影响[J/CD].中华普通外科学文献(电子版),2017,11(6):394-398 .
关键词: 结直肠肿瘤 化学疗法, 辅助 结直肠外科手术 生长抑制因子4 CDX2
英文关键词: Colorectal neoplasms;Chemotherapy, adjuvant;Colorectal surgery;Inhibitor of growth protein 4;CDX2

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