期刊介绍

中华普通外科学文献简介:中华普通外科学文献简介,中华普通外科学文献简介[详细]

期刊信息

主管:
中华人民共和国国家卫生健康委员会
主办:
中华医学会
承办:
中山大学附属第一医院
中山大学附属中山医院
出版:
中华医学电子音像出版社有限责任公司
总编辑: 王深明
编辑部主任: 汪谦
刊 期: 双月刊
创刊时间: 2007年2月
国内刊号: 11-9148/R
国际刊号: 1674-0793
订 购:
中山大学附属第一医院期刊中心
510080, 广州市中山二路58号
电话:(020)87331056
Email:pwwxcma@126.com
定价: 每期28元,全年168元
全文收录:
中国科技核心期刊(中国科技论 文统计源期刊) 中国学术期刊网络出版总库 中文科技期刊数据库(全文版) 中国生物医学期刊引文数据库( CMCI) 美国化学文摘(CA) 首席医学网
首页 > 期刊列表 > 术前CT特征无创预测直肠癌KRAS基因突变的研究
查看全文 下载全文

标题: 术前CT特征无创预测直肠癌KRAS基因突变的研究
摘要:

目的:探讨利用术前多层螺旋CT(MSCT)征象预测直肠癌KRAS基因突变的可能性。方法:回顾性分析2016年10月至2017年12月中山大学附属第一医院52例直肠癌患者的临床病理特征、影像学特征及KRAS基因检测结果。建立二分类Logistics回归模型,推测CT参数预测KRAS基因突变的可能性,受试者工作特征曲线(ROC)分析诊断效果及临界点。结果:KRAS基因突变者18例(34.6%),患者更易发生淋巴结转移(67.6% vs 32.4%,χ2=7.53,P=0.010),直肠上静脉(SRV)直径为(5.07±1.00)mm,显著大于非突变患者的(4.23±1.02)mm,差异有统计学意义(t=2.84,P=0.010)。Logistics回归模型显示,淋巴结转移患者发生基因突变的可能性是无淋巴结转移患者的5.69倍(95% CI: 1.34~24.14),SRV每增加1 mm,基因突变的可能性增加2.56倍(95% CI:1.14~5.73)。SRV的最佳临界点是4.5 mm,结合影像学淋巴结转移,MSCT预测KRAS突变的敏感度为72.22%(13/18),特异度为85.29%(29/34),总体准确性为80.77%(42/52)。结论:利用MSCT静脉期轴位测量SRV直径,可无创预测直肠癌KRAS基因突变可能性,结合淋巴结转移情况,能进一步提高诊断效能。

英文摘要: Objective:To explore the feasibility of predicting KRAS gene mutation in rectal cancer by preoperative multi-slice spiral CT (MSCT). Methods:From October 2016 to December 2017, clinical data of fifty-two patients with rectal cancer in the First Affiliated Hospital of Sun Yat-sen University were analyzed, including the preoperative imaging parameters, pathological data and KRAS gene detection results. Binary Logistic regression models were established to speculate the possibility of predicting KRAS gene mutation by CT parameters, and the diagnostic effect and critical point were analyzed by receiver operating characteristic curve (ROC). Results:Among the 52 cases, 18 cases (34.6%) had KRAS gene mutation and were prone to lymph node metastasis (67.6% vs 32.4%, χ2=7.53, P=0.010). The diameter of superior rectal vein (SRV) was (5.07±1.00) mm in mutation patients, which was significantly larger than that in non-mutation patients (4.23±1.02) mm, the difference was statistically significant (t=2.84, P=0.010). Logistic regression model showed that the probability of gene mutation in patients with lymph node metastasis was 5.69 times higher than that in patients without lymph node metastasis (95% CI: 1.34-24.14). For every 1 mm increase in SRV, the probability of gene mutation increased by 2.56 times (95% CI: 1.14-5.73). The best threshold of SRV was 4.5 mm. Combined with imaging lymph node metastasis, the sensitivity, specificity and accuracy of MSCT in predicting KRAS mutation were 72.22% (13/18), 85.29% (29/34) and 80.77% (42/52), respectively. Conclusions:KRAS mutations in rectal cancer can be predicted noninvasively using MSCT to measure SRV diameter in the axial venous phase. Combined with the presence or absence of lymph node metastasis, the diagnostic efficacy can be improved.
作者:

范真真1;杨艳红2;王猛2;蔡华崧2

作者单位: 洛阳,郑州大学附属洛阳中心医院医学影像科1;广州,中山大学附属第一医院医学影像科2
期刊: 中华普通外科学文献(电子版)
年.卷(期):页码 2020 .14(2):98-102
中图分类号:
文章编号:
引用格式: [1]范真真1;杨艳红2;王猛2;蔡华崧2.术前CT特征无创预测直肠癌KRAS基因突变的研究[J/CD].中华普通外科学文献(电子版),2020,14(2):98-102 .
关键词: 直肠肿瘤;体层摄影术,螺旋计算机;DNA突变分析;KARS基因;直肠上静脉
英文关键词: Rectal neoplasms;Tomography, spiral computed;DNA mutational analysis;KARS genes;Superior rectal vein

欢迎阅读《中华普通外科学文献(电子版)》!您是该文第220位读者!

友情链接