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中华普通外科学文献简介:中华普通外科学文献简介,中华普通外科学文献简介[详细]

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首页 > 期刊列表 > 高危胃肠间质瘤的临床病理特征及预后分析
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标题: 高危胃肠间质瘤的临床病理特征及预后分析
摘要:

目的:分析高危胃肠间质瘤(GIST)临床特征及预后影响因素。方法:回顾性分析2009年8月至2016年2月乐山市人民医院收治的241例高危GIST患者临床资料,分析其临床特征及预后影响因素。结果:男女比例为1.131,年龄构成以中老年为主,40岁以上人群构成比达90.87%(219/241)。原发部位以胃和小肠为主,胃50例(20.75%),小肠121例(50.21%)。首发症状以消化道症状为主,临床表现不典型。R0切除232例(96.27%),术后复发转移率为25.31%(61/241),1、3、5年无复发生存率分别为97.23%、86.56%和75.86%,无复发生存时间为(53.12±13.08)个月。肿瘤最大径(RR=4.780,95% CI:3.716~6.052)、核分裂像(RR=5.411,95% CI:2.195~7.119)是影响高危GIST 5年无复发生存率的独立危险因素,服用靶向药物是保护因素(RR=0.504,95% CI: 0.288~0.883),差异有统计学意义(P<0.001)。结论:高危GIST临床特征不明显,预后受核分裂像、肿瘤最大径和服用靶向药物影响。

英文摘要: Objective:To investigate the clinical characteristics and prognosis of high-risk gastrointestinal stromal tumors (GIST). Methods:The clinical data of two hundred and forty-one high-risk GIST patients admitted to Leshan People’s Hospital from August 2009 to February 2016 were analyzed retrospectively. Results:The proportion of men and women was 1.131. The age composition was mainly middle-aged and old people, and the proportion of people over 40 years old was 90.87% (219/241). The primary sites were stomach and small intestine, with 50 cases (20.75%) in stomach and 121 cases (50.21%) in small intestine. The first symptoms were mainly gastrointestinal symptoms, and the clinical manifestations were not typical. 232 patients (96.27%) underwent R0 resection and the recurrence and metastasis rate was 25.31% (61/241). The recurrence free survival rates of 1-, 3-, 5- year were 97.23%, 86.56% and 75.86%, respectively. The recurrence free survival time was (53.12±13.08) months. The tumor maximum diameter (RR=4.780, 95% CI: 3.716-6.052), mitotic image (RR=5.411, 95% CI: 2.195-7.119) were independent risk factors for 5-year recurrence free survival of high-risk GIST, while taking targeted drugs was the protective factor (RR=0.504, 95% CI: 0.288-0.883), the differences were statistically significant (P<0.001). Conclusion:The clinical features of high-risk GIST are not obvious, and the prognosis is affected by mitotic image, the maximum diameter of the tumor and taking targeted drugs.
作者:

李亚平;朱明杰;蒋鸿元

作者单位: 四川省乐山市人民医院胃肠外科
期刊: 中华普通外科学文献(电子版)
年.卷(期):页码 2020 .14(3):222-225
中图分类号:
文章编号:
引用格式: [1]李亚平;朱明杰;蒋鸿元.高危胃肠间质瘤的临床病理特征及预后分析[J/CD].中华普通外科学文献(电子版),2020,14(3):222-225 .
关键词: 胃肠道间质肿瘤;病理学, 临床;预后;高危
英文关键词: Gastrointestinal stromal tumors; Pathology, clinical; Prognosis; High-risk

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